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ketamine consumption is on the rise as gay guy I know many dudes who have replaced alcohol with ketamine on the weekends in order to party Johnson and Johnson just approved a ketamine derived nasal spray called spado to treat depression and some therapists are putting their patients into a khole in order to treat them so what is ketamine what is it doing to your body and why are so many people taking it right now ketamine AKA Special K is sometimes referred to as a horse tranquilizer because well it is a horse tranquilizer it's also a human tranquilizer in humans at high doses ketamine is in anesthesia in fact remember the 10-day ordeal of the 10 Tha boys and their soccer coach found alive stuck in the cave in
Thailand while Rescuers gave those boys ketamine to sedate and anesthetize them in order to get them out so many drugs will Target one brain system but ketamine is considered a dirty drug which is a legit phological term dirty drugs Target many systems in the brain at once for example ketamine has an effect on the analgesic opiate receptors similar to drugs like heroin and cocaine but ketamine is less active on these neuronal areas compared to those other drugs ketamine has an effect on the hyperpolarization activated cyclic nucleotid gated channels in the brain which can lead to its hypnotic effects but most notably for future widespread use of ketamine it affects the N methyl
de aspartate receptors in your brain along with the neurotransmitter glutamate is a biochemical used in your brain to pass signals from one neuron to another through the synaptic Clift glutamate is a neurochemical in your brain used for neurons to communicate with each other so without glutamate your neurons can't communicate and this is where ketamine comes in at high doses of ketamine enough glutamate is blocked that parts of your brain are turned off this sedates you it causes a rapid loss of consciousness appropriate for general anesthesia high doses of ketamine makes you lose Consciousness whereas at lower doses of ketamine there's actually an increase in glutamine release this
creates an outof Body Experience altered sensory perception and dissociative States it can lead you to feel intoxicated lose your inhibitions it's why gay guys may be using it at the club to grind on each other to siss but it's also ketamine's effect on nmda receptors and glutamate that have made it a promising new drug to deal with severe depression some people I repeat some people feel less depressed after taking doses of ketamine this is because it changes nmda receptors in your brain changes glutamate in your brain and because of your brain's plasticity your brain will actually morph when people are depressed brain cells shrink and neuronal connections change ketamine can
get into the brain and can impact your nmda receptors this can allow brain cells to change and Trigger new connections ketamine may help some depressed people's brains change how they think the relief can also happen fast within 24 hours of a depressive episode if someone gets a subanesthetic dose of ketamine they can feel the relief within a day whereas more conventional anti-depressants like serotonin rupic Inhibitors those can take 3 to 4 months of use before you feel the relief this quick relief is why some doctors are really interested in how ketamine can deal with depressive episodes in one study I read around half the patients saw a benefit from ketamine therapy but about 8% had worse depression after taking ketamine
ketamine being a dirty drug affects many parts of your brain so it's important for you to understand it might not be the right drug to help with depression many people feel better after taking ssris it's up to you and your doctor to work together if you're depressed to understand if ketamine is something that could be beneficial to you but the fact that it could help is why Johnson and Johnson's making a nasal spray called spata that you might see people doing ketamine on the street in the future now let's talk about the dreaded khole ding there's a variety of definitions of a khole but one common thread is that you do so much ketamine that you can't move let's picture a gay guy at a ring 5 to
20 minutes after snorting ketamine he's now consumed an amount that makes him feel high his blood pressure increases his heart rate increases he feels dissociative and toxicated he has changes in his auditory and visual perception he feels Buzzy dreamlike maybe he's a gay guy who finally feels chill this is when said gay guy decides he wants to take some more ketamine as you consume more ketamine you start to feel confused disoriented nauseated unable to feel pain and if you take too much you enter a khole which essentially means you have taken it enough ketamine to anesthetize you anesthetize is that how you say it you've gone from increasing the glutamate to turning it off at this point you may be unable to move yes you
can overdose on ketamine it has less of an effect on your cardiac and lung function compared to like cocaine or heroin but it can be fatal especially when mixed with alcohol or other drugs which when people are partying this can happen Vivian the Dre queen died recently of a potential ketamine overdose as well ketamine use has been shown to impair your memory and cause cognitive issues it can be addictive as well it makes you feel good there's dopamine release as well in rats they would self administer ketamine similar to the way they would cocaine due to its rewarding and reinforcing behaviors as well the breakdown of ketamine in your body can actually impact your bladder and really mess up your urinary system
ketamine can lead to psychotic episodes and make you feel detached from your body and surroundings you can feel grandiose and like you have special powers or special talents people can do impulsive things they could do inadvisable things at work the impact depends on the kind of work this quote is from aamine scientist in a New Yorker article about Elon Musk and how those around him are saying that he's actually doing way more ketamine than ever before in his life he's potentially dependent on ketamine right now which may be why he's acting erratically maybe the guy running America right now has his brain cooked on ketamine the point of this video is to educate you on a drug that's becoming popular and a lot of people are touting
its positive effect effects if you are severely depressed ketamine could be a mode of treatment but it's also a recreational party drug with a lot of serious risks right now ketamine use is on the rise it's becoming very popular so it's important that you stay informed and understand how it actually impacts your body thanks so much for watching and learning about Special K with me we have a link to our podcast on ketamine where we talk a lot more openly about this drug make sure you're subscribe smash that like button and we'll see you soon for a new science video I said Peace
